The event is set to take place in Grenoble, France, from Nov. 23-25, 2018.
The pair, who recently took home the silver medal from their senior international debut at the U.S. International Classic and is competing at Nebelhorn Trophy this weekend, will make their senior Grand Prix Series debut at NHK Trophy Nov. 9-11, 2018.
Lu and Mitrofanov, who train in Plano, Texas, won the U.S. junior title in 2018 and took fifth at the World Junior Championships.
The 2018 ISU Grand Prix of Figure Skating Series will begin with 2018 Skate America on Oct. 19-21 in Everett, Washington. Tickets are available at www.2018SkateAmerica.com.